Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC014
Sex MALE
Dominant hand LEFT
Test date and time 2022-03-11 13:29
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 tbl Madopar HBS 1 uvece

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 15 individuals with a value less than 0.56 were subsequently diagnosed with PD. That is, 35.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.56 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 36, 'TN': 27, 'TP': 6, 'FP': 3}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 15, 'TN': 11, 'TP': 27, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 24, 'TN': 17, 'TP': 18, 'FP': 13}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 40, 'TN': 28, 'TP': 2, 'FP': 2}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.748
timePerCircleCoV 0.189734
timePerCircleSlope -0.0303187
meanError 2.11271
tremorFreq 5.56641
tremorRelPower 37.8881
tremorGyroAmpMean 0.118685
tremorGyroAmpSlope 0.00394783
tremorGyroAmpCoV 0.367928
tremorCoordAmpMean 0.199325
tremorCoordAmpSlope 0.00878897
tremorCoordAmpCoV 0.463276
tremorAccAmpMean 0.184577
tremorAccAmpSlope 0.00759958
tremorAccAmpCoV 0.394669
tremorPcRelVar 0.804917
tremorPcX 0.637053
tremorPcY -0.77082

Circle Segment 1

Duration 8.84 s, Accuracy Estimate 2.284 (lower is better)

Circle Segment 2

Duration 7.04 s, Accuracy Estimate 2.071 (lower is better)

Circle Segment 3

Duration 7.68 s, Accuracy Estimate 2.036 (lower is better)

Circle Segment 4

Duration 8.68 s, Accuracy Estimate 1.698 (lower is better)

Circle Segment 5

Duration 10.68 s, Accuracy Estimate 1.995 (lower is better)

Circle Segment 6

Duration 8.68 s, Accuracy Estimate 1.899 (lower is better)

Circle Segment 7

Duration 5.8 s, Accuracy Estimate 2.203 (lower is better)

Circle Segment 8

Duration 7.12 s, Accuracy Estimate 2.189 (lower is better)

Circle Segment 9

Duration 6.56 s, Accuracy Estimate 2.522 (lower is better)

Circle Segment 10

Duration 6.4 s, Accuracy Estimate 2.231 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 20.404
timePerSpiralCoV 0.152373
timePerSpiralSlope -0.0429506
meanError 2.45134
tremorFreq 6.44531
tremorRelPower 30.3614
tremorGyroAmpMean 0.104038
tremorGyroAmpSlope 0.00154734
tremorGyroAmpCoV 0.395518
tremorCoordAmpMean 0.312082
tremorCoordAmpSlope 0.00127814
tremorCoordAmpCoV 0.440712
tremorAccAmpMean 0.205782
tremorAccAmpSlope 0.00178447
tremorAccAmpCoV 0.391127
tremorPcRelVar 0.769015
tremorPcX -0.483504
tremorPcY 0.875342

Spiral Segment 1

Duration 26.88 s, Accuracy Estimate 2.024 (lower is better)

Spiral Segment 2

Duration 24.2 s, Accuracy Estimate 1.9 (lower is better)

Spiral Segment 3

Duration 21.64 s, Accuracy Estimate 2.6 (lower is better)

Spiral Segment 4

Duration 20.24 s, Accuracy Estimate 2.701 (lower is better)

Spiral Segment 5

Duration 20.68 s, Accuracy Estimate 3.294 (lower is better)

Spiral Segment 6

Duration 18.24 s, Accuracy Estimate 2.358 (lower is better)

Spiral Segment 7

Duration 17.6 s, Accuracy Estimate 1.944 (lower is better)

Spiral Segment 8

Duration 17.12 s, Accuracy Estimate 1.809 (lower is better)

Spiral Segment 9

Duration 18.64 s, Accuracy Estimate 2.965 (lower is better)

Spiral Segment 10

Duration 18.8 s, Accuracy Estimate 2.92 (lower is better)

Elel

eDurationMean 0.631806
eDurationStd 0.293046
eDurationStdnorm 0.463823
eDurationMedian 0.53
eDurationQuartdelta 0.305
eDurationQuartdeltanorm 0.575472
eDurationKurt 6.92682
eDurationTrenddiff -0.2925
eDurationTrendratio 0.612583
eWidthMean 8.42435
eWidthStd 2.23822
eWidthStdnorm 0.265684
eWidthMedian 8.78542
eWidthQuartdelta 2.33214
eWidthQuartdeltanorm 0.265456
eWidthKurt 5.06923
eWidthTrenddiff 0.105892
eWidthTrendratio 1.0122
eHeightMean 19.5631
eHeightStd 5.09861
eHeightStdnorm 0.260624
eHeightMedian 20.826
eHeightQuartdelta 6.42025
eHeightQuartdeltanorm 0.308281
eHeightKurt 6.40907
eHeightTrenddiff -1.90246
eHeightTrendratio 0.913509
eAspectMean 0.456115
eAspectStd 0.173894
eAspectStdnorm 0.381249
eAspectMedian 0.420172
eAspectQuartdelta 0.126058
eAspectQuartdeltanorm 0.300016
eAspectKurt 17.1168
eAspectTrenddiff 0.0292292
eAspectTrendratio 1.07151
eSlantMean -0.154818
eSlantStd 0.217523
eSlantStdnorm -1.40503
eSlantMedian -0.190234
eSlantQuartdelta 0.286148
eSlantQuartdeltanorm -1.50419
eSlantKurt 2.5967
eSlantTrenddiff -0.118052
eRtopMean 0.562059
eRtopStd 0.186435
eRtopStdnorm 0.331699
eRtopMedian 0.542885
eRtopQuartdelta 0.254911
eRtopQuartdeltanorm 0.469549
eRtopKurt 2.09625
eRtopTrenddiff -0.0355589
eRbotMean 0.97649
eRbotStd 0.409409
eRbotStdnorm 0.419266
eRbotMedian 0.999489
eRbotQuartdelta 0.570592
eRbotQuartdeltanorm 0.570884
eRbotKurt 2.73634
eRbotTrenddiff 0.207345
eRrightMean 0.696669
eRrightStd 0.214579
eRrightStdnorm 0.308007
eRrightMedian 0.736916
eRrightQuartdelta 0.195984
eRrightQuartdeltanorm 0.265952
eRrightKurt 11.9651
eRrightTrenddiff -0.069098
eRleftMean 0.531554
eRleftStd 0.143428
eRleftStdnorm 0.269828
eRleftMedian 0.545581
eRleftQuartdelta 0.161158
eRleftQuartdeltanorm 0.295387
eRleftKurt 3.59364
eRleftTrenddiff 0.0480895
lDurationMean 1.16946
lDurationStd 0.373407
lDurationStdnorm 0.319299
lDurationMedian 1.105
lDurationQuartdelta 0.51
lDurationQuartdeltanorm 0.461538
lDurationKurt 2.87866
lDurationTrenddiff -0.2575
lDurationTrendratio 0.786307
lWidthMean 11.8369
lWidthStd 3.38396
lWidthStdnorm 0.285881
lWidthMedian 11.3556
lWidthQuartdelta 3.65659
lWidthQuartdeltanorm 0.322008
lWidthKurt 3.12976
lWidthTrenddiff 1.79113
lWidthTrendratio 1.1741
lHeightMean 58.4438
lHeightStd 11.9473
lHeightStdnorm 0.204424
lHeightMedian 57.681
lHeightQuartdelta 14.6298
lHeightQuartdeltanorm 0.253633
lHeightKurt 4.5277
lHeightTrenddiff 0.590141
lHeightTrendratio 1.01023
lAspectMean 0.21163
lAspectStd 0.0827624
lAspectStdnorm 0.391071
lAspectMedian 0.195383
lAspectQuartdelta 0.0607123
lAspectQuartdeltanorm 0.310735
lAspectKurt 9.61704
lAspectTrenddiff 0.0363631
lAspectTrendratio 1.20269
lSlantMean -0.158461
lSlantStd 0.10409
lSlantStdnorm -0.65688
lSlantMedian -0.180213
lSlantQuartdelta 0.139198
lSlantQuartdeltanorm -0.772407
lSlantKurt 3.55051
lSlantTrenddiff 0.0128758
lRtopMean 0.54095
lRtopStd 0.162349
lRtopStdnorm 0.300118
lRtopMedian 0.556913
lRtopQuartdelta 0.246608
lRtopQuartdeltanorm 0.442813
lRtopKurt 2.32313
lRtopTrenddiff -0.035329
lRbotMean 1.41627
lRbotStd 0.517126
lRbotStdnorm 0.365132
lRbotMedian 1.4522
lRbotQuartdelta 0.716039
lRbotQuartdeltanorm 0.493071
lRbotKurt 2.71718
lRbotTrenddiff -0.255706
lRrightMean 0.739637
lRrightStd 0.200595
lRrightStdnorm 0.271208
lRrightMedian 0.804582
lRrightQuartdelta 0.191668
lRrightQuartdeltanorm 0.238221
lRrightKurt 4.32313
lRrightTrenddiff -0.0751651
lRleftMean 0.735218
lRleftStd 0.120809
lRleftStdnorm 0.164317
lRleftMedian 0.781322
lRleftQuartdelta 0.181349
lRleftQuartdeltanorm 0.232105
lRleftKurt 2.46887
lRleftTrenddiff -0.0419716

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.654343
sumTouchScores 12.4325
meanMovementTime 1.02667
numTouches 19
undershootPercentage 0
overshootPercentage 31.5789

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.468401
sumTouchScores 6.08922
meanMovementTime 1.06917
numTouches 13
undershootPercentage 0
overshootPercentage 53.8462

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 18.944
timePerZigzagCoV 0.0943293
timePerZigzagSlope 0.0190034
meanError 2.33731
tremorFreq 5.66406
tremorRelPower 38.8258
tremorGyroAmpMean 0.15089
tremorGyroAmpSlope 0.00610981
tremorGyroAmpCoV 0.397477
tremorCoordAmpMean 0.251509
tremorCoordAmpSlope 0.00659139
tremorCoordAmpCoV 0.315585
tremorAccAmpMean 0.2419
tremorAccAmpSlope 0.00324157
tremorAccAmpCoV 0.251282
tremorPcRelVar 0.699993
tremorPcX -0.64297
tremorPcY -0.765891

ZigZag Segment 1

Duration 16.68 s, Accuracy Estimate 2.567 (lower is better)

ZigZag Segment 2

Duration 20.52 s, Accuracy Estimate 2.606 (lower is better)

ZigZag Segment 3

Duration 18.28 s, Accuracy Estimate 1.815 (lower is better)

ZigZag Segment 4

Duration 21.0 s, Accuracy Estimate 2.071 (lower is better)

ZigZag Segment 5

Duration 18.24 s, Accuracy Estimate 2.626 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.368
timePerZigzagCoV 0.151874
timePerZigzagSlope -0.0869987
zigzagHeightMean 88.341
zigzagHeightCoV 0.0581401
zigzagHeightSlope -0.0246493
meanError 0.0374107
tremorFreq 5.66406
tremorRelPower 39.561
tremorGyroAmpMean 0.165284
tremorGyroAmpSlope 0.00109739
tremorGyroAmpCoV 0.428109
tremorCoordAmpMean 0.296908
tremorCoordAmpSlope 0.00444353
tremorCoordAmpCoV 0.290109
tremorAccAmpMean 0.258166
tremorAccAmpSlope 0.00121446
tremorAccAmpCoV 0.248975
tremorPcRelVar 0.765472
tremorPcX 0.875758
tremorPcY 0.482751

ZigZag Offset Segment 1

Duration 14.92 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 2

Duration 13.76 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 3

Duration 11.48 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 10.52 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 5

Duration 11.16 s, Accuracy Estimate 0.061 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.75}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.56}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.9520079067362119}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9319255604172081}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}